Title:

The putative role of gut microbiota in cancer: Cysteine is a pivotal coin

 

Objective: 

This review will focus on the role of cysteine as a coin that mediates the metabolic crosstalk between microbiota and cancer. The key points enclose the way cysteine can be made available by the microbiota, by degradation of more complex compounds or by de novo synthesis, in order to contribute to the enrichment of the colonic microenvironment as well to the increase of cysteine systemic bioavailability.

 

Results: 

In gut microbiota equilibrium, cysteine is a major nutrient, not only as a metabolic player but also as a controller of certain pathogenic species, which can overtake microbiota, which is the case of Clostridium difficile.

 

Conclusion:

More studies are needed to reinforce the role of the gut microbiota in the metabolic drift that accompanies aging, in which cysteine is one of the most important coins. 


Full study can be found HERE