Title:

Magnesium Orotate and the Microbiome–Gut–Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders

 

Objective: 

Magnesium orotate has been cited in the medical literature for the past three years as a possible adjuvant in some pediatric and adult gastroenterological disorders associated with dysbiosis. Studies also focus on the possibility of adding magnesium orotate in psychiatric disorders’ treatment, such as major depression and anxiety.

 

Results: 

The first four days of magnesium deficiency, a slightly decreasing Bifidobacterium population was observed. At three weeks, an impressive increase of Lactobacillus and Bifidobacterium was revealed, but within six weeks of magnesium deficiency, a significant decrease of global population diversity was observed.  

 

Conclusion:

The connection between microbiome–gut–brain axis pathophysiology, especially regarding functional gastrointestinal disorders with psychiatric comorbidities in both adults and children, has been demonstrated. Recent studies have shown that magnesium orotate is an important nutrient and adjuvant in the modulation of the microbiome–gut–brain axis.


Full study can be found HERE