Title:

Curcumin attenuates neuroinflammatory damage induced by LPS: Implications for the role of S100B

 

Objective: 

To understand if oral curcumin administration could protect against central nervous system inflammatory damage induced by intracerebroventricular injection of LPS while focusing on astrocyte function

 

Results: 

Curcumin was shown to attenuate inflammatory responses in animal models by diminishing inflammatory cytokine production and thus preventing behavioral alterations caused by neuroinflammation such as weight reduction, lethargy, and anhedonia.

 

Conclusion:

Study provides new information on the effect of oral curcumin administration during neuroinflammatory damage induced by LPS directly administered to the brain


Full study can be found HERE