Title:

Vitamin D and the Host-Gut Microbiome: A Brief Overview

 

Objective: 

There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases.

 

Results: 

A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords “vitamin D,” “intestines,” “gut microflora,” “bowel inflammation”. Only articles published in English and related to the study topic are included in the review. 

 

Conclusion:

Vitamin D possesses anti-inflammatory and immune-modulating effects in the GIT. Many of these functions occur through complex ligand-receptor communication between vitamin D and VDR, and have an influence on the human microbiome. Vitamin D also has important functions in innate and adaptive immunity, intestinal barrier integrity, and gut homeostasis. Vitamin D regulates the gut microbiota, since dysregulation of vitamin D alters microbial imbalance (maladaptation)



Full study can be found HERE