Title:

The role of gut microbiome in the complex relationship between respiratory tract infection and asthma

 

Objective: 

To study the correlation between intestinal flora from the gut microbiome and lung immune function and bridging the role of the gut microbiome to lung health. 

 

Results: 

An increase in Bacteroidetes, a decrease in short-chain fatty acid-producing bacteria such as Firmicutes and Pilospirillum, and an increase in opportunistic pathogens such as Enterococcus have been observed with the pathogenesis of asthma.

 

Conclusion:

Dysregulation of the gut microbiome and reduced metabolic capacity can impair local and pulmonary immunity, thereby increasing susceptibility to lung diseases such as asthma and respiratory viral infections.  A plethora of data supports the notion that gut microbial dysbiosis may contribute to the development of respiratory infections and asthma. This is particularly relevant in the case of children, where microbial changes in early life can have long-lasting effects on immune system maturation and overall health, ultimately increasing the risk of asthma onset and exacerbation.


Full study can be found HERE