Title:

Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation

 

Objective: 

The recent finding of the microbiota–gut–brain axis indicates the bidirectional connection between our gut and brain, demonstrating that gut microbiota can influence many neurological disorders such as autism. Most autistic patients suffer from gastrointestinal (GI) symptoms- this study shows the link between the gut microbiome and aSD and the improvements from focal microbiome transplants 

 

Results: 

Up to 70% of children with ASD have impaired GI function. Within 3 weeks after the foecal microbiome transplant, the anxious mice became more sociable with prompt responsiveness, while extroverted mice became more nervous with delayed responsiveness.

 

Conclusion:

Several factors leading to ASD were identified, mainly early colonization on infant health development and the effect of early microbiota dysbiosis in the gestation period, mode of delivery, uncontrolled usage of antibiotics, and stress. These factors eventually lead to gut microbiome dysbiosis and colonization of pathogenic microbes, which impact the CNS function by the production of neurotoxins. The presence of these pathogenic bacteria, such as Clostridium found in the colon of children, shows the possibility of developing ASD.


Full study can be found HERE